A nonferrous ferroptosis-like strategy for antioxidant inhibition–synergized nanocatalytic tumor therapeutics
Chenyao Wu, Zhonglong Liu, Zhixin Chen, Deliang Xu, Lisong Chen, Han Lin, Jianlin Shi
Abstract
-phosphomolybdic acid nanosheet (CPMNS)–enabled lipid peroxide (LOOH) accumulation via accelerated Mo(V)-Mo(VI) transition, elevated GSH depletion for GPX4 enzyme deactivation, and ROS burst, for efficient ferroptosis and chemotherapy. Both in vitro and in vivo outcomes demonstrate the notable anticancer ferroptosis efficacy, suggesting the high feasibility of this CPMNS-enabled ferroptosis-like therapeutic concept. It is highly expected that such ferroptosis-like design in nanocatalytic medicine would be beneficial to future advances in the field of cancer-therapeutic regimens.
Topics & Concepts
GPX4Lipid peroxidationProgrammed cell deathIn vivoCancer researchAntioxidantChemistryCancer cellCell biologyCancerBiologyBiochemistryApoptosisBiotechnologyCatalaseGeneticsGlutathione peroxidaseFerroptosis and cancer prognosisNanoplatforms for cancer theranosticsAdvanced Nanomaterials in Catalysis