Decrease in work rate in order to keep a constant heart rate: biomarker of exercise intolerance following a 10-day bed rest
Giovanni Baldassarre, Lucrezia Zuccarelli, Giorgio Manferdelli, V. Manfredini, Mauro Marzorati, Andrea Pilotto, Simone Porcelli, Letizia Rasica, Boštjan Šimunič, Rado Pišot, Marco Narici, Bruno Grassi
Abstract
During a 15-min exercise carried out at a heart rate (HR) slightly above that corresponding to the gas exchange threshold, to keep HR constant work rate significantly decreased; the decrease was more pronounced after a 10-day horizontal bed rest. The work rate decrease at a fixed HR can be considered a systemic biomarker of exercise intolerance during microgravity/inactivity and could also be easily and reliably determined during spaceflights or in patients.
Topics & Concepts
Heart rateWork (physics)BiomarkerBed restRest (music)CardiologyInternal medicineWork rateMedicineExercise intoleranceEndocrinologyChemistryHeart failureBlood pressureThermodynamicsPhysicsBiochemistrySpaceflight effects on biologyHigh Altitude and HypoxiaThermoregulation and physiological responses