Divergent Construction of Thiochromanes and <i>N</i>-Arylbutanamides via Arylthiodifluoromethyl Radical-Triggered Cascade of Alkenes
Yu Sun, Shupeng Zhang, Wenchao Yang
Abstract
A strategy utilizing silver-catalyzed oxidative decarboxylation radical cascade cyclization of arylthiodifluoroacetic acids with alkenes for the simple and efficient preparation of difluoromethylated thiochromanes and 2,2-disubstituted- N -arylbutanamides derivatives has been developed. This approach includes good functional group tolerance, easily accessible starting materials, and operational simplicity.
Topics & Concepts
ChemistryCascadeSimplicityDecarboxylationRadical cyclizationCombinatorial chemistryAlkeneOrganic chemistrySimple (philosophy)Functional groupCatalysisChromatographyEpistemologyPolymerPhilosophyFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCatalytic C–H Functionalization Methods