Novel synthesis naringenin-benzyl piperazine derivatives prevent glioblastoma invasion by inhibiting the hypoxia-induced IL6/JAK2/STAT3 axis and activating caspase-dependent apoptosis
Ömer Zaim, Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Hafize Özcan, Mohamed M. Zreigh, Ayşe Kardelen Kurtdere
Topics & Concepts
ChemistryApoptosisPiperazineNaringeninHypoxia (environmental)Caspase 3STAT3Caspase 8Cell biologyStereochemistryBiochemistryFlavonoidProgrammed cell deathOrganic chemistryBiologyOxygenAntioxidantCytokine Signaling Pathways and Interactionsinterferon and immune responsesGenomics, phytochemicals, and oxidative stress