Hepatoprotective, cytotoxic, antimicrobial and antioxidant activities of <i>Dioon spinulosum</i> leaves Dyer Ex Eichler and its isolated secondary metabolites
Walaa A. Negm, Kamilia A. Abo El-Seoud, Amal Kabbash, Amira Kassab, Mona El‐Aasr
Abstract
-sitosterol (3), stigmasterol (4), oliveriflavone (5), 7,4',7″,4″'-tetramethylamentoflavone (6), 7,4',7''-trimethylamentoflavone (7), scaidopitysin (8), bilobetin (9), isoginkgetin (10), aromadendrin (11), sotusflavone (12), engeletin (14) and eriocitrin (17) for the first time together with amentoflavone (13). Compounds (11) and (13) displayed very strong cytotoxic activity and showed the highest protective activity against DNA damage.
Topics & Concepts
AmentoflavoneChemistryPhytochemicalApigeninTraditional medicineAntimicrobialStigmasterolAntioxidantBiochemistryFlavonoidMedicineOrganic chemistryChromatographyBiological Activity of Diterpenoids and BiflavonoidsPhytochemicals and Antioxidant ActivitiesPhytochemistry and Biological Activities