Uniform soluble support for the large-scale synthesis of sequence-defined macromolecules
Irene De Franceschi, Chiel Mertens, Nezha Badi, Filip Du Prez
Abstract
A monodisperse soluble support is used as an effective tool for the large-scale, liquid-phase synthesis of sequence-defined macromolecules. This uniform support allows for direct characterisation and leads to a single peak in mass spectrometry.
Topics & Concepts
MacromoleculeDispersitySequence (biology)Scale (ratio)Phase (matter)Mass spectrometryChemistryChromatographyMaterials scienceChemical engineeringOrganic chemistryPhysicsBiochemistryEngineeringQuantum mechanicsMass Spectrometry Techniques and ApplicationsAnalytical Chemistry and ChromatographyChemical Synthesis and Analysis