A Quadruple Catalysis Enabling Intermolecular Branch‐Selective Hydroacylation of Styrenes
Yunosuke Takekawa, Masanari Nakagawa, Kazunori Nagao, Hirohisa Ohmiya
Abstract
A quadruple N-heterocyclic carbene/cobalt/photoredox/Brønsted base catalysis to realize branch-selective hydroacylation of styrenes with aromatic and aliphatic aldehydes is demonstrated. This protocol allows access to branched ketones from readily available materials in an atom-economical manner. The quadruple catalysis can transfer a formyl hydrogen of aldehydes as a hydrogen radical equivalent onto the terminal carbon of an alkene by controlled electron and proton transfers.
Topics & Concepts
HydroacylationIntermolecular forceCatalysisChemistryComputer scienceOrganic chemistryAldehydeMoleculeCatalytic C–H Functionalization MethodsAsymmetric Hydrogenation and CatalysisCatalytic Cross-Coupling Reactions