Rhodium‐Catalyzed Atroposelective Click Cycloaddition of Azides and Alkynes
Linwei Zeng, Jiaming Li, Sunliang Cui
Abstract
The cycloaddition of azides and alkynes is the leading click chemistry technology and has been widely used in drug discovery, biology and material sciences. However, the development of a modular and scalable enantioselective click cycloaddition remains a long-standing challenge. Herein, we report a rhodium-catalyzed enantioselective click cycloaddition of azides and alkynes for rapid and modular access to atropisomeric triazoles in excellent yields and enantioselectivities. The process is mild, efficient and scalable, and features broad substrate scope.
Topics & Concepts
CycloadditionRhodiumCatalysisChemistryClick chemistryCombinatorial chemistryOrganic chemistryMedicinal chemistryAxial and Atropisomeric Chirality SynthesisSynthesis and Catalytic ReactionsClick Chemistry and Applications