Harnessing ROS-Induced Oxidative Stress for Halting Colorectal Cancer <i>via</i> Thiazolidinedione-Based SOD Inhibitors
Mohamed N. Abd Al Moaty, El Sayed H. El Ashry, Laila F. Awad, Asmaa Mostafa, Marwa M. Abu‐Serie, Mohamed Teleb
Abstract
diminished the antioxidant activities of SOD (by 29.7, 70.1, and 33.3%, respectively), ALDH1A (by 85.92, 95.84, and 86.48%, respectively), and GPX (by 50.17, 87.03, and 53.28%, respectively) in the treated Caco-2 cells, elevating the Caco-2 cellular content of ROS by 21.42, 7.863, and 8.986-folds, respectively. Docking simulations were conducted to display their possible binding modes and essential structural features. Also, their physicochemical parameters and pharmacokinetic profiles formulating drug-likeness were computed.
Topics & Concepts
Oxidative stressReactive oxygen speciesSuperoxide dismutaseChemistryDoxorubicinAntioxidantGlutathione peroxidaseThiazolidinedionePharmacologyColorectal cancerBiochemistryCancer cellCancerCancer researchBiologyMedicineInternal medicineChemotherapyEndocrinologyType 2 diabetesDiabetes mellitusSynthesis and biological activityGenomics, phytochemicals, and oxidative stressGlutathione Transferases and Polymorphisms