Commentary: Trem2 Deletion Reduces Late-Stage Amyloid Plaque Accumulation, Elevates the Aβ42:Aβ40 Ratio, and Exacerbates Axonal Dystrophy and Dendritic Spine Loss in the PS2APP Alzheimer's Mouse Model
Sachchida Nand, Vivek K. Chaturvedi, Brijesh Kumar Singh, Mohan Singh
Abstract
Accumulating pieces of evidence have shown that microglia have both protective as well as detrimental impacts depending upon the stage of the disease A number of mutations have been reported in microglial genes that are linked with increased AD risk. The triggering receptor expressed on myeloid cells 2 (Trem2) is one of the most critical AD risk genes found in microglia. In animal models and human studies as well, several experiments have been performed which showed that Trem2 and its variants effectively modulate the function of microglia. Trem2 effectively alters the microglial functions such as activation, proliferation, phagocytosis, inflammation, survival, and metabolism.