Midline-1 regulates effector T cell motility in experimental autoimmune encephalomyelitis via mTOR/microtubule pathway
Yingying Wei, Wenjuan Li, Jie Huang, Zachary Braunstein, Xinxin Liu, Xinlu Li, Jeffrey A. Deiuliis, Jun Chen, Xinwen Min, Handong Yang, Quan Gong, Leya He, Zheng Liu, Lingli Dong, Jixin Zhong
Abstract
Our data suggests that Mid1 regulates effector T cell migration to the central nervous system via mTOR/microtubule pathway in EAE, and thus may serve as a potential therapeutic target for the treatment of MS.
Topics & Concepts
Experimental autoimmune encephalomyelitisAdoptive cell transferImmunologyT cellProinflammatory cytokineBiologyCell biologyMultiple sclerosisInflammationImmune systemT-cell and B-cell ImmunologyCytokine Signaling Pathways and InteractionsImmunotherapy and Immune Responses