Peptidomimetics and Peptide-Based Blockbuster Drugs
Jianlin Han, Hiroyuki Konno, Tatsunori Sato, Kunisuke Izawa, Vadim A. Soloshonok
Abstract
Amino acids (AAs) play an important role in the modern health industry. The aim of this article was to assess that AAs’ residues are frequently found in the structures of smallmolecule modern pharmaceuticals, while peptidomimetics and peptide-based drugs are entirely derived from AAs. Currently, AAs serve as key structural features in numerous successful pharmaceuticals, so-called blockbuster drugs. In this work, we provide a detailed profile of 5 peptidomimetics and 4 peptide drugs. For each compound, we describe the spectrum of biological activity, medicinal chemistry discovery, and synthetic preparation.
Topics & Concepts
PeptidomimeticChemistryPeptideBroad spectrumCombinatorial chemistryNanotechnologyPharmacologyBiochemistryMedicineMaterials scienceChemical Synthesis and AnalysisComputational Drug Discovery MethodsClick Chemistry and Applications