Magnetic Resonance Imaging Detects Chronic Rhinosinusitis in Infants and Preschool Children with Cystic Fibrosis
Olaf Sommerburg, Mark O. Wielpütz, Jan-Philipp Trame, Felix Wuennemann, Elzbieta Opdazaite, Mirjam Stahl, Michael Puderbach, Annette Kopp‐Schneider, Eva Fritzsching, Hans‐Ulrich Kauczor, Ingo Baumann, Marcus Mall, Monika Eichinger
Abstract
Abstract Rationale Chronic rhinosinusitis (CRS) contributes to disease burden of patients with cystic fibrosis (CF). However, its onset and progression in infants and preschool children with CF remain poorly understood. Objectives To determine the prevalence and extent of CRS in young children with CF using magnetic resonance imaging (MRI). Methods MRI was performed in sedation in 67 infants and preschool children with CF (mean age 2.3 ± 2.1 yr; range 0–6 yr) and 30 non-CF control subjects (3.5 ± 2.0 yr; range 0–6 yr). Paranasal sinus dimensions and structural abnormalities, including mucosal swelling; mucopyoceles; and nasal polyps of the maxillary, frontal, sphenoid, and ethmoid sinuses; and, in addition, medial maxillary sinus wall deformation, were assessed using a dedicated CRS MRI scoring system. Results Pneumatization and dimensions of paranasal sinuses did not differ between the two groups. MRI detected an increased prevalence of mucosal swelling (83% vs. 17%; P < 0.001), mucopyoceles (75% vs. 2%; P < 0.001), polyps (26% vs. 7%; P < 0.001), and maxillary sinus wall deformation (68% vs. 2%; P < 0.001) in infants and preschool children with CF compared with age-matched control subjects. Furthermore, the extent of these abnormalities was also increased with a MRI sum score of 22.9 ± 10.9 in CF compared with 4.5 ± 7.6 in non-CF control subjects (P < 0.001). Conclusions MRI detected normal dimensions of paranasal sinuses, and a high prevalence and severity of paranasal sinus abnormalities due to CRS in infants and preschool children with CF without radiation exposure. Our results support the development of MRI for sensitive noninvasive diagnosis and monitoring of CRS in young children with CF, and as outcome measures for clinical trials. Clinical trial registered with www.clinicaltrials.gov (NCT00760071).