Rational Design of a Novel Dual-Functional Fluorescent Probe for Simultaneous Monitoring and Imaging of Mitochondrial CO and ATP Fluctuations during Drug-Induced Liver Injury without Spectral Crosstalk
Xin Zhou, Yuhan Luo, Shixiong Jin, Tongtong Xu, Yueyin Liang, Zhiyuan Meng, Xu Xu, Shifa Wang, Zhonglong Wang
Abstract
. This work not only realizes the bidirectional channel imaging of CO and ATP in vivo and in vitro but also provides a powerful tool for the early diagnosis and therapy of DILI.
Topics & Concepts
ChemistryFluorescenceBiophysicsRhodamineIn vivoRational designMitochondrionCrosstalkEndogenyLiver injuryOxidative phosphorylationOxidative stressBiochemistryIn vitroAggregation-induced emissionFörster resonance energy transferMembrane potentialFluorescence-lifetime imaging microscopyPreclinical imagingATP synthaseMetabolismAdenosine triphosphateSpectral imagingCarbon monoxideATP-sensitive potassium channelEnergy metabolismSulfur Compounds in BiologyMolecular Sensors and Ion DetectionEicosanoids and Hypertension Pharmacology