Silencing of hsa_circ_0101145 reverses the epithelial-mesenchymal transition in hepatocellular carcinoma via regulation of the miR-548c-3p/LAMC2 axis
Jinglan Jin, Huan Liu, Meishan Jin, Wanyu Li, Hongqin Xu, Wei Feng
Abstract
. In summary, the findings illustrated that hsa_circ_0101145 silencing suppressed HCC progression by functioning as an miR-548c-3p sponge to enhance LAMC2 expression. Therefore, hsa_circ_0101145 could be an HCC treatment target.
Topics & Concepts
Gene silencingDownregulation and upregulationHepatocellular carcinomaCancer researchCell growthFlow cytometryMetastasisEpithelial–mesenchymal transitionCell cultureBiologyTransfectionCancerMolecular biologyGeneGeneticsBiochemistryCircular RNAs in diseasesMicroRNA in disease regulationCancer-related molecular mechanisms research