Synthesis of new oxadiazol-phthalazinone derivatives with anti-proliferative activity; molecular docking, pro-apoptotic, and enzyme inhibition profile
Mohamed H. Hekal, Abeer M. El‐Naggar, Fatma S. M. Abu El‐Azm, Wael M. El‐Sayed
Abstract
: Compound 1 had the best profile on the gene and protein levels (arresting cell cycle and inducing apoptosis). The ability of compounds 1 and 2e to inhibit both MAPK and Topo II nominates these derivatives as potential candidates for further anticancer and antitumor studies.
Topics & Concepts
ApoptosisChemistryDocking (animal)Cell growthEnzymeCyclin-dependent kinase 1Cell cycleCell cycle checkpointCell cultureMAPK/ERK pathwayBiochemistryStereochemistrySignal transductionBiologyMedicineNursingGeneticsSynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Biological Evaluation