Isoamphipathic antibacterial molecules regulating activity and toxicity through positional isomerism
Swagatam Barman, Sudip Mukherjee, Logia Jolly, Cassandra Troiano, Alessandro Grottesi, Debajyoti Basak, Paolo Calligari, Brinta Bhattacharjee, Gianfranco Bocchinfuso, Lorenzo Stella, Jayanta Haldar
Abstract
activity against MRSA wound infection in a murine model with no detectable dermal toxicity. Altogether, the report explored the design and development of isoamphipathic antibacterial molecules to establish the role of positional isomerism in achieving selective and potential antibacterial agents.
Topics & Concepts
ToxicityAntibacterial activityChemistryMoleculeComputational biologyStereochemistryPharmacologyCombinatorial chemistryBiologyGeneticsBacteriaOrganic chemistryAntimicrobial Peptides and ActivitiesPhenothiazines and Benzothiazines Synthesis and ActivitiesAntimicrobial agents and applications