Radical bicyclization of 1,6-enynes with sulfonyl hydrazides by the use of TBAI/TBHP in the aqueous phase
Fa-Liang Liu, Mei Lan, Ling‐Tao Wang, Yu Zhou, Keqi Tang, Ting Li, Rongnan Yi, Wen‐Ting Wei
Abstract
-butyl hydroperoxide (TBHP) combined system is reported. The resulting reaction of diverse nitrogen- and oxygen-polyheterocycles displays high chemical selectivity, high step-economy, and a moderate substrate scope. Moreover, iodosulfonylation can be realized by modulating the structure of the 1,6-enynes.
Topics & Concepts
SulfonylChemistrySubstrate (aquarium)Aqueous solutionSelectivityAqueous two-phase systemIodidePhase (matter)Combinatorial chemistryOrganic chemistryCatalysisAlkylBiologyEcologySulfur-Based Synthesis TechniquesRadical Photochemical ReactionsCatalytic C–H Functionalization Methods