An unexpected role of an extra phenolic hydroxyl on the chemical reactivity and bioactivity of catechol or gallol modified hyaluronic acid hydrogels
Sumanta Samanta, Vignesh Kumar Rangasami, N. Arul Murugan, Vijay Singh Parihar, Oommen P. Varghese, Oommen P. Oommen
Abstract
Gallic acid-functionalized materials possess superior tissue-adhesive, antioxidant, and immunomodulatory properties due to the lower p<italic>K</italic><sub>a</sub>and faster oxidation kinetics, making them superior to dopamine derivatives for biomedical applications.
Topics & Concepts
CatecholGallic acidHyaluronic acidChemistryReactivity (psychology)Self-healing hydrogelsAntioxidantOrganic chemistryAdhesiveKineticsCombinatorial chemistryPolymer chemistryLayer (electronics)GeneticsBiologyMedicinePathologyQuantum mechanicsPhysicsAlternative medicineFree Radicals and AntioxidantsOptical Imaging and Spectroscopy TechniquesCircadian rhythm and melatonin