TBAF Effects 3,6-Anhydro Formation from 6-<i>O</i>-Tosyl Pyranosides
Zachary A. Morrison, Mark Nitz
Abstract
3,6-Anhydro sugars are common structures in algal polysaccharides and occur in the furanodictine and sauropunol natural products. We have found that treatment of 6-O-tosylpyranosides with tetrabutylammonium fluoride provides a mild, high-yielding synthesis of 3,6-anhydro sugars. Using O-glycoside substrates, 3,6-anhydropyranosides are isolated and the use of N,O-dimethyl hydroxylamine glycosides yields 3,6-anhydrofuranosides. Applying this approach, concise synthetic routes to several 3,6-anhydro sugar natural products are reported, including furanodictine A and sauropunols A–D.
Topics & Concepts
ChemistryTosylStereochemistryMedicinal chemistryOrganic chemistryCombinatorial chemistryEnzyme Catalysis and ImmobilizationCarbohydrate Chemistry and SynthesisPolyamine Metabolism and Applications