Synthesis, biological evaluation and molecular modeling study of [1,2,4]-Triazolo[4,3-c]quinazolines: New class of EGFR-TK inhibitors
Wafaa A Ewes, Mohammad A. Elmorsy, Shahenda M. El‐Messery, Magda N.A. Nasr
Topics & Concepts
ChemistryGefitinibHeLaCytotoxicityMTT assayEGFR inhibitorsLipinski's rule of fiveDocking (animal)IC50In vitroEpidermal growth factor receptorPharmacologyStereochemistryBiochemistryReceptorIn silicoBiologyNursingGeneMedicineQuinazolinone synthesis and applicationsCancer Mechanisms and TherapyCancer therapeutics and mechanisms