Divergent syntheses of spirooxindoles from oxindole-embedded four-membered synthon <i>via</i> cycloaddition reactions
Hongjin Shi, Liang Wang, Shuai‐Shuai Li, Yongjun Liu, Lubin Xu
Abstract
The construction of five and six membered heterocycle fused spirooxindoles was achieved <italic>via</italic> the [4 + 1] and formal [4 + 2] cycloadditions between our rationally designed four-membered synthons and pyridinium methylides and α-bromoacetophenones, respectively.
Topics & Concepts
SynthonChemistryPyridiniumCycloadditionOxindoleCombinatorial chemistryStereochemistryOrganic chemistryCatalysisAsymmetric Synthesis and CatalysisCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions