Ribose Moieties Acylation and Characterization of Some Cytidine Analogs
Kazi M. Rana, Jannatul Ferdous, Sarkar M. A. Kawsar, Anowar Hosen
Abstract
Modification of naturally occurring nucleosides is an important area in the search for new agents with therapeutic potential. In this study, nucleoside molecules, that is, cytidine analogs bearing ribose moieties were successfully synthesized to obtain 5´-O-acyl cytidine (2), which in turn was converted into 2´,3´-di-O-acyl cytidine (3–7) through direct acylation. Similarly, several cytidine analogs (8–15) were formed using the aforementioned technique. Physicochemical properties and spectroscopic methods were used to characterize the newly synthesized cytidine analogs. X-ray powder diffraction was employed for quantitatively identifying crystalline compounds. Hence, these synthesized derivatives can be used as potential antimicrobial agents and promising drug candidates