Homologation of Ketones: Direct Transformation of Alkyl Ketones to Aryl Ketones via Photoredox Catalyzed Deacylation-Aroylation Sequence
Tian Wang, Zengyu Zhang, Fan Gao, Xiaoyu Yan
Abstract
Ketones, as essential functional group skeletons, have garnered significant interest due to their diverse transformations. Herein, we describe a versatile photoredox catalyzed deacylation-aroylation strategy that enables the direct transformation of alkyl ketones to aryl ketones. This process involves photoredox deacylation of dihydroquinazolinones derived from alkyl ketones to generate alkyl radicals, followed by subsequent NHC-catalyzed or NHC-mediated radical aroylation.
Topics & Concepts
ChemistryAlkylPhotoredox catalysisArylCatalysisKetoneTransformation (genetics)RadicalMedicinal chemistryOrganic chemistryPhotocatalysisGeneBiochemistryRadical Photochemical ReactionsCatalytic C–H Functionalization MethodsSulfur-Based Synthesis Techniques