The phytochemical brazilin suppress DNMT1 expression by recruiting p53 to its promoter resulting in the epigenetic restoration of p21 in MCF7cells
Biji Chatterjee, Krishna Ghosh, Aishwarya Swain, Kirankumar Nalla, Haritha Ravula, Archana Pan, Santosh R. Kanade
Topics & Concepts
DNA methylationDNMT1EpigeneticsBiologyEpigenetic therapyDNA methyltransferaseCarcinogenesisCancer researchMethylationChromatin immunoprecipitationCell cycleMethyltransferaseCpG siteGene silencingMolecular biologyPromoterGene expressionCancerGeneGeneticsBiological Stains and PhytochemicalsSynthesis and bioactivity of alkaloidsBeetle Biology and Toxicology Studies