AIE-active two-photon fluorescent nanoprobe with NIR-II light excitability for highly efficient deep brain vasculature imaging
Soham Samanta, Meina Huang, Shaoqiang Li, Zhigang Yang, Ying He, Zhenyu Gu, Jianguo Zhang, Dan Zhang, Liwei Liu, Junle Qu
Abstract
Robust noninvasive 2D and 3D two-photon (NIR-II light, 1040 nm) brain vasculature imaging with beneficial attributes such as outstanding penetration depth (800 µm) and exceptional spatial resolution (1.92 µm), were achieved by utilizing AIETP NPs in this study.
Topics & Concepts
AmphiphileBiocompatibilityNanoparticleFluorescenceFluorophoreNanoprobePolymerChemistryPhotochemistryPreclinical imagingMaterials scienceNanotechnologyBiophysicsIn vivoOrganic chemistryCopolymerBiotechnologyQuantum mechanicsBiologyPhysicsLuminescence and Fluorescent MaterialsNanoplatforms for cancer theranosticsNonlinear Optical Materials Studies