Glioma-targeted delivery of exosome-encapsulated antisense oligonucleotides using neural stem cells
Tomasz Adamus, Chia-Yang Hung, Chunsong Yu, Elaine Kang, Mohamed Hammad, Linda Flores, Sergey Nechaev, Qifang Zhang, Joanna Gonzaga, Kokilah Muthaiyah, Piotr Swiderski, Karen S. Aboody, Marcin Kortylewski
Abstract
with CpG-STAT3ASO inhibited subcutaneous tumor growth more effectively than the equivalent amount of oligonucleotide alone. Based on these results, we anticipate that NSCs and NSC-derived exosomes will provide a clinically relevant strategy to improve delivery and safety of oligonucleotide therapeutics for glioma treatment.
Topics & Concepts
GliomaMicrovesiclesNeural stem cellCancer researchExosomeBiologyCell biologyStem cellmicroRNABiochemistryGeneExtracellular vesicles in diseaseMicroRNA in disease regulationRNA Interference and Gene Delivery