A Plasmodium falciparum ATP-binding cassette transporter is essential for liver stage entry into schizogony
Debashree Goswami, Sudhir Kumar, William J. Betz, Janna Armstrong, Meseret T. Haile, Nelly Camargo, Chaitra Parthiban, Annette M. Seilie, Sean C. Murphy, Ashley M. Vaughan, Stefan H. I. Kappe
Abstract
ABCC2 is an expression marker for early phases of parasite liver infection and plays an essential role in the successful initiation of liver stage replication.
Topics & Concepts
SchizogonyPlasmodium falciparumTransporterATP-binding cassette transporterPlasmodium (life cycle)MalariaBiologyCell biologyComputational biologyChemistryBiochemistryImmunologyGeneParasite hostingComputer scienceWorld Wide WebDrug Transport and Resistance MechanismsMalaria Research and ControlLiver Disease and Transplantation