Eosinophil Deficiency Promotes Aberrant Repair and Adverse Remodeling Following Acute Myocardial Infarction
Iqbal Toor, Dominik Rückerl, Iris Mair, Rob Ainsworth, Marco Meloni, Ana‐Mishel Spiroski, C Bénézech, Jennifer M. Felton, Adrian Thomson, Andrea Caporali, Thomas Keeble, Kare Tang, Adriano G. Rossi, David E. Newby, Judith E. Allen, Gillian A. Gray
Abstract
In ST-segment elevation myocardial infarction of both patients and mice, there was a decline in blood eosinophil count, with activated eosinophils recruited to the infarct zone. Eosinophil deficiency resulted in attenuated anti-inflammatory macrophage polarization, enhanced myocardial inflammation, increased scar size, and deterioration of myocardial structure and function. Adverse cardiac remodeling in the setting of eosinophil deficiency was prevented by interleukin-4 therapy.
Topics & Concepts
MedicineEosinophilMyocardial infarctionVentricular remodelingInflammationCardiologyInternal medicineMacrophageBiochemistryIn vitroAsthmaChemistryCardiac Fibrosis and RemodelingEosinophilic Disorders and SyndromesSignaling Pathways in Disease