A peptide-based aggregation-induced emission bioprobe for selective detection and photodynamic killing of Gram-negative bacteria
Pingping Bao, Cong Li, Hanlin Ou, Shenglu Ji, Yao Chen, Jing Gao, Xin Yue, Jing Shen, Dan Ding
Abstract
Herein, we report a new bioprobe with aggregation-induced emission (AIE) characteristics by conjugation of a far-red/near-infrared emissive AIE luminogen and two polymyxinB peptides. Due to the strong binding effect between polymyxin B and the lipopolysaccharide in the cell wall of Gram-negative bacteria, the bioprobe can selectively visualize Gram-negative bacteria and effectively kill them via photodynamic treatment.
Topics & Concepts
ChemistryBacteriaAggregation-induced emissionPeptideGram-negative bacteriaPolymyxin BPolymyxinPhotodynamic therapyCombinatorial chemistryLipopolysaccharideBiophysicsBiochemistryFluorescenceBiologyAntibioticsEscherichia coliOrganic chemistryQuantum mechanicsGeneticsPhysicsGeneEndocrinologyNanoplatforms for cancer theranosticsLuminescence and Fluorescent MaterialsAntimicrobial Peptides and Activities