Pathogenesis and Transmissibility of North American Highly Pathogenic Avian Influenza A(H5N1) Virus in Ferrets
Joanna A. Pulit-Penaloza, Jessica A. Belser, Nicole Brock, Poulami Basu Thakur, Terrence M. Tumpey, Taronna R. Maines
Abstract
Highly pathogenic avian influenza A(H5N1) viruses have spread rapidly throughout North American flyways in recent months, affecting wild birds in over 40 states. We evaluated the pathogenicity and transmissibility of a representative virus using a ferret model and examined replication kinetics of this virus in human respiratory tract cells.
Topics & Concepts
Influenza A virus subtype H5N1Transmissibility (structural dynamics)Highly pathogenicVirologyPathogenicityBiologyVirusInfluenza A virusPathogenesisViral replicationAvian influenza virusRespiratory tractMicrobiologyImmunologyRespiratory systemVibration isolationAnatomyQuantum mechanicsPhysicsVibrationInfluenza Virus Research StudiesAnimal Disease Management and EpidemiologyViral Infections and Vectors