The auxiliary glutamate receptor subunit dSol-1 promotes presynaptic neurotransmitter release and homeostatic potentiation
Beril Kiragasi, Pragya Goel, Sarah L. Perry, Yifu Han, Xiling Li, Dion Dickman
Abstract
is necessary to rapidly increase the abundance of DKaiR1D receptors near active zones during homeostatic signaling. Together with recent work showing the CUB domain protein Neto2 is necessary for the homeostatic modulation of postsynaptic GluRs in mammals, our data demonstrate that dSol-1 is required for the homeostatic regulation of presynaptic GluRs. Thus, we propose that CUB domain proteins are fundamental homeostatic modulators of GluRs on both sides of the synapse.
Topics & Concepts
Glutamate receptorHomeostatic plasticityKainate receptorNeurotransmitter receptorNeurotransmitterLong-term potentiationCell biologyBiologyNeuroscienceHomeostasisAMPA receptorSynaptic plasticityReceptorChemistryMetaplasticityBiochemistryCentral nervous systemNeurobiology and Insect Physiology ResearchGenetics, Aging, and Longevity in Model OrganismsCellular transport and secretion