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New imidazole-2-ones and their 2-thione analogues as anticancer agents and CAIX inhibitors: Synthesis, in silico ADME and molecular modeling studies

Seham A. Ibrahim, Saedah R. Al‐Mhyawi, Faten M. Atlam

2023Bioorganic Chemistry17 citationsDOI

Topics & Concepts

ChemistryADMEIn silicoImidazoleCombinatorial chemistryDocking (animal)Small moleculeMolecular modelLipinski's rule of fiveMoleculeDrug discoveryAnticancer drugIn vitroStereochemistryDrugBiochemistryOrganic chemistryPharmacologyGeneMedicineNursingEnzyme function and inhibitionSynthesis and biological activitySynthesis and Characterization of Heterocyclic Compounds
New imidazole-2-ones and their 2-thione analogues as anticancer agents and CAIX inhibitors: Synthesis, in silico ADME and molecular modeling studies | Litcius