Anticancer Activity of Mannich Bases: A Review of Recent Literature
Gheorghe Roman
Abstract
This report summarizes the latest published data on the antiproliferative action and cytotoxic activity of Mannich bases, a structurally heterogeneous category of chemical entities that includes compounds which are synthesized via the grafting of an aminomethyl function onto diverse substrates by means of the Mannich reaction. The present overview of the topic is an update to the information assembled in a previously published review that covered the literature up to 2014.
Topics & Concepts
Mannich reactionChemistryCombinatorial chemistryFunction (biology)Organic chemistryBiologyGeneticsCatalysisSynthesis and biological activityClick Chemistry and ApplicationsChemical Synthesis and Analysis