Inflation of polygenic risk scores caused by sample overlap and relatedness: Examples of a major risk of bias
Colin A. Ellis, Karen Oliver, Rebekah V. Harris, Ruth Ottman, Ingrid E. Scheffer, Heather C Mefford, Michael P. Epstein, Samuel F. Berkovic, Melanie Bahlo
Topics & Concepts
BiobankGenome-wide association studySample size determinationSample (material)Summary statisticsGenetic associationComputer sciencePolygenic risk scoreStatisticsEconometricsData scienceBiologyBioinformaticsGeneticsSingle-nucleotide polymorphismMathematicsChromatographyChemistryGenotypeGeneGenetic Associations and EpidemiologyGenetics and Neurodevelopmental DisordersGenomic variations and chromosomal abnormalities