KLK8/HGF/Met signaling pathway mediates diabetes-associated hippocampal neuroinflammation in male mice
Dan‐Hong Xu, Xiaoyong Zhang, Shiyu Liu, Juan Wei, Junhui Zhan, Jian-Kui Du, Yujian Liu, Xiaoyan Zhu
Abstract
This study provides evidence that the KLK8/HGF/Met signaling pathway mediates diabetes-associated hippocampal neuroinflammation and depression-like behaviors, highlighting the therapeutic potential of targeting this pathway in diabetes-associated depression.
Topics & Concepts
NeuroinflammationHippocampal formationSignal transductionDiabetes mellitusNeuroscienceMedicineCell biologyChemistryCancer researchEndocrinologyInternal medicineBiologyInflammationNeuroinflammation and Neurodegeneration MechanismsApelin-related biomedical researchNeurogenesis and neuroplasticity mechanisms