A floating 5 μm-diameter needle electrode on the tissue for damage-reduced chronic neuronal recording in mice
Koji Yamashita, Hirohito Sawahata, Shota Yamagiwa, Shohei Yokoyama, Rika Numano, Kowa Koida, Takeshi Kawano
Abstract
a surgical method. The electrode is placed on the brain tissue of a mouse with a dissolvable material, reducing the physical stress to the tissue; this is followed by the implantation of the electrode device in the brain without fixing it to the cranium, achieving a floating electrode architecture on the tissue. The electrode shows stable recording with no significant degradation of the signal-to-noise ratios for 6 months, and minimized tissue damage is confirmed compared to that when using a cranium-fixed electrode with the same needle geometry.
Topics & Concepts
Brain tissueMicroelectrodeElectrodeBiomedical engineeringMaterials scienceMedicineChemistryPhysical chemistryNeuroscience and Neural EngineeringEEG and Brain-Computer InterfacesPhotoreceptor and optogenetics research