Iodine‐Catalyzed Double [4+2] Oxidative Annulations for the Synthesis of Bipyrazines from Ketones and Diamines by a Domino Strategy
Yuxin Ding, Ruiqin Zhang, Renchao Ma, Yongmin Ma
Abstract
Abstract An iodine‐catalyzed double [4+2] oxidative annulation of ketones and diamines is described. A multi‐pathway coupled domino strategy has been developed for the synthesis of substituted dimeric pyrazines under metal‐free conditions. One C−C and four C−N bonds are formed during this double [4+2] oxidative annulation process from two ketones and two diamines. magnified image
Topics & Concepts
ChemistryDominoAnnulationIodineCatalysisOxidative phosphorylationDouble bondCombinatorial chemistryOrganic chemistryStereochemistryMedicinal chemistryBiochemistrySynthesis and Biological EvaluationCatalytic C–H Functionalization MethodsMulticomponent Synthesis of Heterocycles