Diverse meibum lipids produced by Awat1 and Awat2 are important for stabilizing tear film and protecting the ocular surface
Megumi Sawai, Keisuke Watanabe, Kana Tanaka, Wataru Kinoshita, Kento Otsuka, Masatoshi Miyamoto, Takayuki Sassa, Akio Kihara
Abstract
KO mice, and most of these in DKO mice. Our findings reveal that Awat1 and Awat2 show characteristic substrate specificity and together produce diverse meibum lipids.
Topics & Concepts
WaxAcyltransferasesChemistryBiochemistryBiosynthesisGeneOcular Surface and Contact Lensmelanin and skin pigmentationAdvancements in Transdermal Drug Delivery