Targeting HDAC3 to overcome the resistance to ATRA or arsenic in acute promyelocytic leukemia through ubiquitination and degradation of PML-RARα
Bo Dai, Feng Wang, Ying Wang, Jiayan Zhu, Yunxuan Li, Tingting Zhang, Luyao Zhao, Lining Wang, Wenhui Gao, Junmin Li, Hong‐Hu Zhu, Ke Li, Jiong Hu
Topics & Concepts
Arsenic trioxideAcute promyelocytic leukemiaHDAC3Cancer researchSUMO proteinPromyelocytic leukemia proteinTXNIPTretinoinRetinoic acidBiologyChemistryApoptosisUbiquitinCell cultureHistoneBiochemistryHistone deacetylaseGeneticsOxidative stressGeneThioredoxinRetinoids in leukemia and cellular processesHistone Deacetylase Inhibitors ResearchProtein Degradation and Inhibitors