Design, eco-friendly synthesis, and molecular docking studies of isatin hybrids as promising therapeutic agents (anticancer, anticholinesterase inhibitor, α-glucosidase inhibitor, and anti-MRSA)
Israa A. Seliem
Abstract
). Molecular docking backed up these findings by showing good binding interactions with the active sites of the target enzymes. The results indicate that compound 5 is a promising candidate for developing multifunctional agents. It could have potential uses in managing neurodegenerative, metabolic, and infectious diseases.
Topics & Concepts
IsatinChemistryCoumarinBiological activityDocking (animal)HybridDrugCombinatorial chemistryEnzymeBiochemistryMCF-7Cancer cellEnzyme inhibitionComputational biologyCancer cell linesCell cultureActive siteCancerBreast cancerCytotoxicityPharmacologyRational designStructure–activity relationshipLead compoundCancer treatmentSynthesis and biological activityClick Chemistry and ApplicationsCancer therapeutics and mechanisms