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Quercetin attenuates cisplatin-induced mitochondrial apoptosis via PI3K/Akt mediated inhibition of oxidative stress in pericytes and improves the blood labyrinth barrier permeability

Tian-lan Huang, Wenjun Jiang, Zan Zhou, Tian-feng Shi, Miao Yu, Meng Yu, Junqiang Si, Yanping Wang, Li Li

2024Chemico-Biological Interactions24 citationsDOI

Topics & Concepts

OtotoxicityPharmacologyOxidative stressPI3K/AKT/mTOR pathwayApoptosisProtein kinase BChemistryReactive oxygen speciesMitochondrial permeability transition poreCisplatinCell biologyBiologyMedicineBiochemistryProgrammed cell deathInternal medicineChemotherapySaffron Plant Research StudiesElectron Spin Resonance StudiesNeurological Disease Mechanisms and Treatments
Quercetin attenuates cisplatin-induced mitochondrial apoptosis via PI3K/Akt mediated inhibition of oxidative stress in pericytes and improves the blood labyrinth barrier permeability | Litcius