To Each Villain Its Plot: The Case of <i>Candida auris</i>
Marco Cassone, Lona Mody
Abstract
EditorialsNovember 2021To Each Villain Its Plot: The Case of Candida aurisMarco Cassone, MD, PhD and Lona Mody, MD, MScMarco Cassone, MD, PhDDivision of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MichiganSearch for more papers by this author and Lona Mody, MD, MScDivision of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, and Geriatric Research and Education Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, MichiganSearch for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/M21-3456 SectionsAboutFull TextPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail Candida auris is not the first nor will it be the last emerging pathogen, but it poses unique challenges because of its physiology, its epidemiology, and the unique clinical settings in which it manifests. Only recently recognized as an opportunistic pathogen of major clinical importance (1, 2) and endowed with a puzzling evolutionary history (3), C auris shares many characteristics with other successful pathogens, such as ease of transmission, environmental hardiness (4), and increasing rates of resistance to the already limited therapeutic options (5). Among the peculiar aspects that distinguish it from other Candida species are its speed of global ...References1. Lee WG, Shin JH, Uh Y, et al. First three reported cases of nosocomial fungemia caused by Candida auris. J Clin Microbiol. 2011;49:3139-42. [PMID: 21715586] doi:10.1128/JCM.00319-11 CrossrefMedlineGoogle Scholar2. Kim MN, Shin JH, Sung H, et al. Candida haemulonii and closely related species at 5 university hospitals in Korea: identification, antifungal susceptibility, and clinical features. Clin Infect Dis. 2009;48:e57-61. [PMID: 19193113] doi:10.1086/597108 CrossrefMedlineGoogle Scholar3. Chow NA, Muñoz JF, Gade L, et al. Tracing the evolutionary history and global expansion of Candida auris using population genomic analyses. m. Bio. 2020;11. [PMID: 32345637] doi:10.1128/mBio.03364-19 CrossrefMedlineGoogle Scholar4. Welsh RM, Bentz ML, Shams A, et al. Survival, persistence, and isolation of the emerging multidrug-resistant pathogenic yeast Candida auris on a plastic health care surface. J Clin Microbiol. 2017;55:2996-3005. [PMID: 28747370] doi:10.1128/JCM.00921-17 CrossrefMedlineGoogle Scholar5. Kean R, Ramage G. Combined antifungal resistance and biofilm tolerance: the global threat of Candida auris. m. Sphere. 2019;4. [PMID: 31366705] doi:10.1128/mSphere.00458-19 CrossrefMedlineGoogle Scholar6. Brown JL, Delaney C, Short B, et al. Candida auris phenotypic heterogeneity determines pathogenicity in vitro. m. Sphere. 2020;5. [PMID: 32581078] doi:10.1128/mSphere.00371-20 CrossrefMedlineGoogle Scholar7. Chowdhary A, Tarai B, Singh A, et al. Multidrug-resistant Candida auris infections in critically ill coronavirus disease patients, India, April–July 2020. Emerg Infect Dis. 2020;26:2694-2696. [PMID: 32852265] doi:10.3201/eid2611.203504 CrossrefMedlineGoogle Scholar8. Eyre DW, Sheppard AE, Madder H, et al. A Candida auris outbreak and its control in an intensive care setting. N Engl J Med. 2018;379:1322-1331. [PMID: 30281988] doi:10.1056/NEJMoa1714373 CrossrefMedlineGoogle Scholar9. Centers for Disease Control and Prevention. Identification of Candida auris. Accessed at www.cdc.gov/fungal/candida-auris/identification.html on 30 July 2021. Google Scholar10. Karmarkar E, O’Donnell K, Prestel C, et al. Rapid assessment and containment of Candida auris transmission in postacute care settings—Orange County, California, 2019. Ann Intern Med. 2021;174:1554-62. doi:10.7326/M21-2013 Google Scholar Author, Article, and Disclosure InformationAuthors: Marco Cassone, MD, PhD; Lona Mody, MD, MScAffiliations: Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, Ann Arbor, MichiganDivision of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, and Geriatric Research and Education Clinical Center, VA Ann Arbor Healthcare System, Ann Arbor, MichiganDisclosures: Authors have reported no disclosures of interest. Forms can be viewed at www.acponline.org/authors/icmje/ConflictOfInterestForms.do?msNum=M21-3456.Corresponding Author: Lona Mody, MD, Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, 300 North Ingalls Road, Room 905, Ann Arbor, MI 48109; e-mail, [email protected] Author Addresses: Dr. Cassone: Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, 109 Zina Pitcher Place, Room 3023, Ann Arbor, MI 48109.Dr. Mody: Division of Geriatric and Palliative Care Medicine, Department of Internal Medicine, Michigan Medicine, and Geriatric Research Education and Clinical Center, VA Ann Arbor Healthcare System, 300 North Ingalls Road, Room 905, Ann Arbor, MI 48104.This article was published at Annals.org on 7 September 2021. PreviousarticleNextarticle Advertisement FiguresReferencesRelatedDetailsSee AlsoRapid Assessment and Containment of Candida auris Transmission in Postacute Care Settings—Orange County, California, 2019 Ellora N. Karmarkar , Kathleen O’Donnell , Christopher Prestel , Kaitlin Forsberg , Lalitha Gade , Seema Jain , Douglas Schan , Nancy Chow , Darby McDermott , John Rossow , Mitsuru Toda , Ryan Ruiz , Sopheay Hun , Jennifer L. Dale , Annastasia Gross , Tyler Maruca , Janet Glowicz , Richard Brooks , Hosniyeh Bagheri , Teresa Nelson , Nicole Gualandi , Zenith Khwaja , Sam Horwich-Scholefield , Josh Jacobs , Michele Cheung , Maroya Walters , Kara Jacobs-Slifka , Nimalie D. Stone , Lydia Mikhail , Sudha Chaturvedi , Liore Klein , Paula Snippes Vagnone , Emily Schneider , Elizabeth L. Berkow , Brendan R. Jackson , Snigdha Vallabhaneni , Matthew Zahn , and Erin Epson Metrics November 2021Volume 174, Issue 11Page: 1622-1623KeywordsCandidaClinical epidemiologyMultidrug resistanceOpportunistic pathogens ePublished: 7 September 2021 Issue Published: November 2021 Copyright & PermissionsCopyright © 2021 by American College of Physicians. All Rights Reserved.PDF downloadLoading ...