ALLETHRIN INDUCED TOXICOPATHOLOGICAL ALTERATIONS IN ADULT MALE ALBINO RATS
Ahrar Khan
Abstract
This study was designed to investigate the allethrin induced toxico-pathological changes in adult male albino rats. A total of 60 adult male albino rats were divided randomly into 4 equal groups. Group A served as control. Groups B, C and D were administered orally Allethrin @ 0.5, 1.0 and 1.5g/kg body for 14 experiment days, respectively. Dullness, erected hairs, alopecia, less response towards feed and water, watery droppings, tremors, convulsions and coma were more prominent signs in treated groups. Feed intake and body weight decreased in all treated groups. Mortality was recorded in group C and D. The total erythrocyte and leukocyte counts, hemoglobin concentration and packed cell volume decreased significantly (P0.05) in all allethrin treated groups as compared to the control group. Histopathologically, kidneys exhibited condensed nuclei, necrotic tubules and congested renal parenchyma. In liver, vacuolar degeneration in nucleus and cytoplasm was observed. Micro nucleated lymphocytes were also evident in group D treated with the highest dose of allethrin. In conclusion, allethrin induced dose and time dependent toxico-pathological effects in adult male albino rats.