A COF-based anti-interference nanoplatform for intracellular nucleic acid imaging
Peng Gao, Mengzhen Wang, Xiuyan Wan, Xiaohan Liu, Wei Pan, Na Li, Bo Tang
Abstract
We demonstrate here that a porphyrin covalent organic framework-based nanoplatform could effectively avoid the interference of proteins and biothiols and result in high-fidelity signals in intracellular mRNA imaging.
Topics & Concepts
Nucleic acidPorphyrinInterference (communication)IntracellularCovalent bondChemistryFidelityNanotechnologyRNA interferenceBiophysicsBiochemistryRNAMaterials scienceComputer scienceBiologyOrganic chemistryTelecommunicationsGeneChannel (broadcasting)Advanced biosensing and bioanalysis techniquesLuminescence and Fluorescent MaterialsMolecular Sensors and Ion Detection