Absence of familiarity triggers hallmarks of autism in mouse model through aberrant tail-of-striatum and prelimbic cortex signaling
Sebastian Krüttner, Antonio Falasconi, Sergio Valbuena, Ivan Galimberti, Tewis Bouwmeester, Silvia Arber, Pico Caroni
Abstract
mice by the chemogenetic activation of PreL→TS projection neurons. Environmental enrichment prevented ASD-like phenotypes by obviating the dependence on PreL→TS activity. Therefore, novel context experience has a key role in triggering ASD-like phenotypes in genetically predisposed mice, and behavioral therapies involving familiarity and enrichment might prevent the emergence of ASD phenotypes.
Topics & Concepts
NeuroscienceStriatumInfralimbic cortexAutismVentral striatumCortex (anatomy)PsychologyOptogeneticsPrefrontal cortexBiologyDopamineCognitionDevelopmental psychologyAutism Spectrum Disorder ResearchGenetics and Neurodevelopmental DisordersNeurogenesis and neuroplasticity mechanisms