Meta-Analysis of Caenorhabditis elegans Transcriptomics Implicates Hedgehog-Like Signaling in Host-Microbe Interactions
Alejandra Zárate-Potes, Irtiqa Ali, Margarida Ribeiro Camacho, Hayley Brownless, Alexandre Benedetto
Abstract
), as well as commensal-specific host-gene expression changes that are required for normal host stress handling. Importantly, interactions appeared more microbe-specific than shared. Our results thus implicate the Hedgehog-like signaling pathway in the modulation and possibly fine-tuning of nematode-microbe interactions and support the idea that interventions targeting this pathway may provide a new avenue for anthelmintic development.
Topics & Concepts
BiologyCaenorhabditis elegansTranscriptomeRNA interferenceGeneComputational biologyGeneticsHedgehogContext (archaeology)Hedgehog signaling pathwayInnate immune systemGene expressionImmune systemRNAPaleontologyGenetics, Aging, and Longevity in Model OrganismsParasites and Host InteractionsGut microbiota and health