Regulation of telomere homeostasis and genomic stability in cancer by <i>N</i> <sup>6</sup> -adenosine methylation (m <sup>6</sup> A)
Ji Hoon Lee, Juyeong Hong, Zhao Zhang, Bárbara de la Peña Avalos, Cecilia J. Proietti, Agustina Roldán Deamicis, Pablo Guzmán G, Hung‐Ming Lam, José M. Garcia, Martine P. Roudier, Anthony Sisk, Richard de la Rosa, Kevin Vu, Mei Yang, Yiji Liao, Jessica Scheirer, Douglas Pechacek, Pooja Yadav, Manjeet K. Rao, Siyuan Zheng, Teresa L. Johnson‐Pais, Robin J. Leach, Patricia V. Elizalde, Eloïse Dray, Kexin Xu
Abstract
mRNA levels show the opposite patterns. Our work suggests that the cancer-driving genomic alterations may potentially be fixed by rectifying particular epitranscriptomic program.
Topics & Concepts
TelomereGenome instabilityDNA methylationCancerHomeostasisMethylationAdenosineBiologyGeneticsCancer researchGeneCell biologyDNABiochemistryGene expressionDNA damageRNA modifications and cancerEpigenetics and DNA MethylationCancer-related gene regulation