Shifting into high gear: how interstitial cells of Cajal change the motility pattern of the developing intestine
Nicolas R. Chevalier, Yanis Ammouche, Anthony Gomis, Clémence Teyssaire, Pascal de Santa Barbara, Sandrine Faure
2020American Journal of Physiology-Gastrointestinal and Liver Physiology40 citationsDOIOpen Access PDF
Abstract
We reveal a sharp transition from smooth muscle to interstitial cell of Cajal (ICC)-driven motility in the chicken embryo, leading to higher-frequency, more rhythmic contractile waves. We predict the transition to happen between 12 and 14 embryonic wk in humans. We image for the first time the onset of ICC activity in an embryonic gut by calcium imaging. We show the first KIT and anoctamin-1 (ANO1) in situ hybridization micrographs in the embryonic chicken gut.
Topics & Concepts
Interstitial cell of CajalMotilityCell biologyIn situ hybridizationBiologyEmbryonic stem cellEmbryoEmbryogenesisAnatomyEnteric nervous systemSmooth muscleNeuroscienceEndocrinologyBiochemistryGeneGene expressionGastrointestinal motility and disordersCaveolin-1 and cellular processesDiet and metabolism studies