Requirement of Gαi1 and Gαi3 in interleukin-4-induced signaling, macrophage M2 polarization and allergic asthma response
Jinyu Bai, Ya Li, Guanhua Xue, Ke-ran Li, Yufan Zheng, Zhi-qing Zhang, Qin Jiang, Yuan-yuan Liu, Xiaozhong Zhou, Cong Cao
Abstract
These findings highlight novel and essential roles for Gαi1/3 in regulating IL-4-induced signaling, macrophage M2 polarization and allergic asthma response.
Topics & Concepts
Macrophage polarizationAllergic asthmaAsthmaInterleukin 4ImmunologyAllergic responseSignal transductionMedicineMacrophageChemistryCell biologyBiologyCytokineImmunoglobulin EIn vitroBiochemistryAntibodyImmune cells in cancerCytokine Signaling Pathways and InteractionsImmune Response and Inflammation